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Contraindicated (1)pentobarbital will lower the level or effect of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or impact of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Double brexpiprazole dose over 1-two months if administered